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Fleet's laboratories in Hampshire UK

Alastair Dent FRSC


Managing Director, Quality Director 

Has 35 years of experience in process development and manufacture for companies including ICI, Kodak and Johnson & Johnson. He is a former chair of the Analytical Biosciences committee of the Royal Society of Chemistry, and is an author and consultant in process development, GMP, experimental design and conjugation chemistry.


Development of a non-radioactive immunoassay for thyroxine binding globulin. Christofides, N.D., Dent, A.H. et al. (1987). J. Endocrinol., 112, supplement.

Development of a rapid non-radioactive assay for digoxin based on enhanced luminescence. Mashiter, K., Dent, A.H. et al. (1987). Development of a rapid non-radioactive assay for digoxin based on enhanced luminescence. Clin. Chem., 33, p. 1015.

Development of a non-radioactive assay for cortisol based on enhanced luminescence. Bacarese-Hamilton, A.J., Dent, A.H. et al. (1987). J. Endocrinol., 115, supplement.

Development of a single incubation enzyme immunoassay for antibodies to rubella virus based on enhanced luminescence. Holian, J., Dent, A. et al. (1988). Clin. Chem., 34, p. 1316.

Labelled antibody assay for free T4. Sheehan, C., Dent, A. et al. (1989). Clin. Chem., 35, pp. 1148-9.

Enhanced luminescence competitive immunoassay for anti-HIV. Crouch, C., Dent, A.H. et al. (1989). Clin. Chem., 35, p. 1207.

Development of a rapid non-radioactive immunoassay for LH based on enhanced luminescence. J. Endocrinol., 121, supplement. Montague, D.J., Dent, A. et al. (1989).

Enhanced luminescence assay for anti-HBs. T.E., Dent, A. et al. (1990). Clin. Chem., 36, p. 1089.

Enhanced luminescence immunoassay for antibodies to hepatitis B core antigen (aHBc). Weston, S.M., Dent, A. et al. (1990). Clin. Chem., 36, p. 1089.

An integrated approach to the development, transfer, and validation of manufacturing processes. Truran, P.L. and Dent, A.H. (1999). J. Validation Technol., 5, pp. 241-6.

Protein conjugation serves life science applications. Dent, A.H. (2005). sp2, 4, pp. 18-20.

Plugging the knowledge gap: the role of contract service providers in conjugated biopharmaceutical development. Dent, A.H. (2006). Contract Services Europe, Sep.2006, pp. 29-32.

Optimizing bioconjugation processes. Dent, A.H. (2007). Pharmaceutical Technology Europe, 19, pp. 39-46.

Impact of Bioconjugation on Structure and Function of Antibodies for Use in Immunoassay by Hydrogen-Deuterium Exchange Mass Spectrometry. Luckau L, Groves K, Blencowe C, Scrimshaw S, Dent A, Quaglia M. Front Mol Biosci. 2022 Jul



Martin, J.K., Dent, A.H et al. (1986). Enzyme assay of body fluids. World Patent 86/07462, to Amersham International plc.


Bioconjugation: Protein Coupling Techniques for the Biomedical Sciences, M Aslam, A Dent, published by Macmillan (1998), ISBN0333583752

Conjugation methods in The Immunoassay Handbook, 2nd, 3rd and 4th Edns. (Wild, D., Ed.), published by Macmillan (2000, 2005, 2013), ISBN 978-0-08-097037-0

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