Fleet Bioprocessing Ltd. have a proud history of meeting our customers’ contract service needs – even when these are sometimes hard to categorise!
With high quality standards and flexible and resourceful staff, we often rise to the challenge of “difficult” jobs which can be hard to outsource. If it’s within our capabilities we’ll always try to help.
Examples of this type include:
Clean-up of “vintage” antibody stocks to reduce bioburden to an acceptable level for use.
Acid treatment of glass vials for radiopharmaceutical use.
Pooling, blending and dilution of raw material batches to make them compatible with the customer’s processes.
If you’re not sure whether Fleet might be able to help you with a tricky job, it costs nothing to ask - contact us via our enquiry form here and we’ll do our best to help.
Fleet take over vial treatment procedure at short notice for radiopharmaceutical vendor - and continue routine production for nearly two decades!
In 2001 Fleet were asked to set up a procedure for acid treatment of glass vials at short notice, as the customer's existing contractor had unexpectedly gone out of business. A GMP production process was rapidly developed and documented to meet this need, and nearly twenty years later we have made over 70 batches of this product!
Antibody-coated particle stability improved by cross-linking chemistry
The Fleet chemistry team have an extensive conjugation toolbox, allowing us to comfortably tackle atypical as well as standard conjugation challenges. Carrying out research for a leader in the UK diagnostics sector, Fleet helped establish an improved method for stabilising an antibody-particle conjugate, chemically cross-linking the antibody without significantly impacting its binding activity.
Creating a mass-based assay standard from an antibody
In an unusual challenge, Fleet have used innovative conjugation and purification strategies to help a customer develop a reliable and predictable procedure to "shift" the molecular weight of a protein in a quantitiative fashion, allowing it to be employed as a mass-based assay standard.